NPTX2 Antibodies

Neurons are interconnected by multiple synapses. Synaptic dysfunction is an early-stage indicator of neurodegeneration and appears to correlate to the degree of cognitive decline1. Neuronal Pentraxin 2 (NPTX2) is a synapse‑derived protein that can be measured in cerebrospinal fluid (CSF), plasma and serum, and reduced CSF levels have been associated with synaptic dysfunction1. It could potentially be a relevant biomarker for observing disease evolution or treatment response in patients with neurodegenerative diseases such as dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), Parkinson's disease (PD) and psychiatric disorders such as schizophrenia2,3. In addition, it may represent an important therapeutic target for TDP-43 proteinopathies4.

The ADx409 and ADx410 monoclonal antibodies can be used to develop immunoassays for detecting NPTX2, supporting further characterization of this synaptic marker.
 

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ADx409 - mAb mouse anti pentraxin 2

Product number 90578

1 mg
ADx410 - mAb mouse anti pentraxin

Product number 90582

1 mg

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