Neurogranin Antibodies

Neurogranin is a postsynaptic protein concentrated in dendritic spines, where it contributes to synaptic signaling and plasticity. Cerebrospinal fluid (CSF) neurogranin levels are elevated in Alzheimer’s disease and correlate with synaptic loss and cognitive decline¹. Neurogranin also shows differential expression across neurodegenerative conditions, and is elevated in other forms of neuronal injury, supporting its relevance as a synaptic biomarker^2,3. The truncated P75 isoform is the form of neurogranin predominantly found in CSF and blood, and assay comparison studies demonstrate that different neurogranin assays, despite targeting different epitopes, provide similar diagnostic information⁴.

The ADx403 and ADx451 monoclonal antibodies targeting neurogranin enable the development of immunoassays for quantifying this synaptic marker.