INNOTEST® PHOSPHO-TAU(181P)

INNOTEST PHOSPHO-TAU_(181P) is a solid-phase enzyme immunoassay for the quantitative determination of phosphorylated Tau (Phospho-Tau_(181P)) in human cerebrospinal fluid (CSF).

The combined use of CSF-Tau and CSF-β-amyloid_(1-42) marker concentrations allows differentiation between Alzheimer’s disease (AD) and normal aging or other neurological diseases such as depression.^1-5

The discrimination of AD from non-AD types of dementia such as dementia with Lewy Bodies may be further improved using the quantification of CSF-phospho-Tau₍₁₈₁₎.^6-7

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INNOTEST® PHOSPHO-TAU(181P)

Product number 81574

96 Tests

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Features & Benefits

User-friendly enzyme immunoassay, standard technology

Generic and color-coded components

Easily automated on microplate processor (generic components)

Ready-to-use Calibrators reduce inter and intra run variation

Run Validation Controls for assay run validation

Sample volume: 75 µL CSF. Duplicate testing is strongly recommended and requires 2 x 75 µL CSF.

Limit of Detection: 13 pg/mL
Calibrator range: 15,6 to 1000 pg/mL

This assay should be used in combination with the PHOSPHO-TAU CAL-RVC pack, article no. 81575.

References

Andreasen et al. Evaluation of CSF-tau and CSF- Aβ42 as diagnostic markers for Alzheimer’s disease in clinical practice. Arch Neurol 2001;58:373-379.

Hansson et al. Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234

Mattsson et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009; 302(4): 385-393.

Tabaraud et al. Alzheimer CSF biomarkers in routine clinical setting. Acta Neurol Scand. 2012; 125(6): 416-23

Buchhave et al. Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012; 69(1): 98-106.

Vanmechelen et al. CSF-phospho-tau (181P) as a promising marker for discriminating Alzheimer’s disease from dementia with Lewy bodies. In: Iqbal K, Sisodia SS, Winblad B. Alzheimer’s disease: Advances in etiology, pathogenesis and therapeutics. Chichester: John Wiley & Sons; 2001. p. 285-291.

De Vreese et al. Discrimination of dementia with Lewy bodies from Alzheimer’s disease via determination of the phospho-tau concentration in cerebrospinal fluid. 18th International Conference of Alzheimer’s Disease. Barcelona, Spain, October 23-26, 2002.

Additional useful information about Alzheimer’s disease can be found on the following websites:

The Alzheimer forum site:

http://www.alzforum.org/new/detail.asp?id=875

http://www.alzforum.org/new/detail.asp?id=804

http://www.alzforum.org/new/detail.asp?id=709
Documentation
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Other documents

File

List_of_recommended_reading_publications_for_INNOTEST_Neuro.pdf (pdf, 154.35 kb)

File

INNOTEST Alzheimer panel brochure (pdf, 642.33 kb)

File

Whitepaper - Biomarkers for Alzheimers disease.pdf (pdf, 148.72 kb)

File

Practical guide for lumbar puncture.pdf (pdf, 263.94 kb)

File

NeuroSig v6-0 macro for use with INNOTEST Neuro assays (vnd.ms-excel.sheet.macroEnabled.12, 214.10 kb)

Extra information

This macro is used with all Neuro INNOTEST assays for calculating the concentrations based on the OD values obtained by a plate reader.
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Insights

Alzheimer's disease

Improvement of AD risk scores by use of the Aβ1-42/Aβ1-40 ratio

Different scores have been developed to provide an interpretation of biomarker results for AD diagnosis or risk prediction. Here we will give two...

Jan 20, 2020

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Alzheimer's disease

Aβ1-42/Aβ1-40 ratio for interpretation of discordant results

By use of the Aβ1-42/Aβ1-40 ratio, discordant results (i.e. when amyloid and tau biomarkers are not concordant) can be improved. However, while the...

Jan 9, 2020

Read more

Alzheimer's disease

Use of the Aβ1-42/Aβ1-40 ratio to improve accuracy of AD diagnosis

It is widely agreed that, since cerebrospinal fluid (CSF) is in direct contact with the central nervous system (CNS), analytes measured in this body...

Nov 22, 2019

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INNOTEST® PHOSPHO-TAU(181P)

Details

Features & Benefits

References

Documentation

Get access to this section and more

Other documents

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Insights

Related products

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