INNOTEST® PHOSPHO-TAU(181P)

INNOTEST PHOSPHO-TAU_(181P) is a solid-phase enzyme immunoassay for the quantitative determination of phosphorylated Tau (Phospho-Tau_(181P)) in human cerebrospinal fluid (CSF).

The combined use of CSF-Tau and CSF-β-amyloid_(1-42) marker concentrations allows differentiation between Alzheimer’s disease (AD) and normal aging or other neurological diseases such as depression.^1-5

The discrimination of AD from non-AD types of dementia such as dementia with Lewy Bodies may be further improved using the quantification of CSF-phospho-Tau₍₁₈₁₎.^6-7

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INNOTEST® PHOSPHO-TAU(181P)

Product number 81574

96 Tests

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User-friendly enzyme immunoassay, standard technology

Generic and color-coded components

Easily automated on microplate processor (generic components)

Ready-to-use Calibrators reduce inter and intra run variation

Run Validation Controls for assay run validation

Sample volume: 75 µL CSF. Duplicate testing is strongly recommended and requires 2 x 75 µL CSF.

Limit of Detection: 13 pg/mL
Calibrator range: 15,6 to 1000 pg/mL

This assay should be used in combination with the PHOSPHO-TAU CAL-RVC pack, article no. 81575.

References

Andreasen et al. Evaluation of CSF-tau and CSF- Aβ42 as diagnostic markers for Alzheimer’s disease in clinical practice. Arch Neurol 2001;58:373-379.

Hansson et al. Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234

Mattsson et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009; 302(4): 385-393.

Tabaraud et al. Alzheimer CSF biomarkers in routine clinical setting. Acta Neurol Scand. 2012; 125(6): 416-23

Buchhave et al. Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012; 69(1): 98-106.

Vanmechelen et al. CSF-phospho-tau (181P) as a promising marker for discriminating Alzheimer’s disease from dementia with Lewy bodies. In: Iqbal K, Sisodia SS, Winblad B. Alzheimer’s disease: Advances in etiology, pathogenesis and therapeutics. Chichester: John Wiley & Sons; 2001. p. 285-291.

De Vreese et al. Discrimination of dementia with Lewy bodies from Alzheimer’s disease via determination of the phospho-tau concentration in cerebrospinal fluid. 18th International Conference of Alzheimer’s Disease. Barcelona, Spain, October 23-26, 2002.

Additional useful information about Alzheimer’s disease can be found on the following websites:

The Alzheimer forum site:

http://www.alzforum.org/new/detail.asp?id=875

http://www.alzforum.org/new/detail.asp?id=804

http://www.alzforum.org/new/detail.asp?id=709
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Other documents

File

List_of_recommended_reading_publications_for_INNOTEST_Neuro.pdf (pdf, 154.35 kb)

File

INNOTEST Alzheimer panel brochure (pdf, 642.33 kb)

File

Whitepaper - Biomarkers for Alzheimers disease.pdf (pdf, 148.72 kb)

File

Practical guide for lumbar puncture.pdf (pdf, 263.94 kb)

File

NeuroSig v6-0 macro for use with INNOTEST Neuro assays (vnd.ms-excel.sheet.macroEnabled.12, 214.10 kb)

Extra information

This macro is used with all Neuro INNOTEST assays for calculating the concentrations based on the OD values obtained by a plate reader.
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INNOTEST® PHOSPHO-TAU(181P)

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