INNOTEST® PHOSPHO-TAU(181P)

INNOTEST PHOSPHO-TAU_(181P) is a solid-phase enzyme immunoassay for the quantitative determination of phosphorylated Tau (Phospho-Tau_(181P)) in human cerebrospinal fluid (CSF).

The combined use of CSF-Tau and CSF-β-amyloid_(1-42) marker concentrations allows differentiation between Alzheimer’s disease (AD) and normal aging or other neurological diseases such as depression.^1-5

The discrimination of AD from non-AD types of dementia such as dementia with Lewy Bodies may be further improved using the quantification of CSF-phospho-Tau₍₁₈₁₎.^6-7

CE marked

INNOTEST® PHOSPHO-TAU(181P)

Product number 81574

96 Tests

Contact sales for information and inquiries

Please contact your local Fujirebio representative for the availability of this product in your country.

Click here to navigate

Details
Documentation
Insights
Related products
Product inquiry

Details
Features & Benefits

User-friendly enzyme immunoassay, standard technology

Generic and color-coded components

Easily automated on microplate processor (generic components)

Ready-to-use Calibrators reduce inter and intra run variation

Run Validation Controls for assay run validation

Sample volume: 75 µL CSF. Duplicate testing is strongly recommended and requires 2 x 75 µL CSF.

Limit of Detection: 13 pg/mL
Calibrator range: 15,6 to 1000 pg/mL

This assay should be used in combination with the PHOSPHO-TAU CAL-RVC pack, article no. 81575.

References

Andreasen et al. Evaluation of CSF-tau and CSF- Aβ42 as diagnostic markers for Alzheimer’s disease in clinical practice. Arch Neurol 2001;58:373-379.

Hansson et al. Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234

Mattsson et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009; 302(4): 385-393.

Tabaraud et al. Alzheimer CSF biomarkers in routine clinical setting. Acta Neurol Scand. 2012; 125(6): 416-23

Buchhave et al. Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012; 69(1): 98-106.

Vanmechelen et al. CSF-phospho-tau (181P) as a promising marker for discriminating Alzheimer’s disease from dementia with Lewy bodies. In: Iqbal K, Sisodia SS, Winblad B. Alzheimer’s disease: Advances in etiology, pathogenesis and therapeutics. Chichester: John Wiley & Sons; 2001. p. 285-291.

De Vreese et al. Discrimination of dementia with Lewy bodies from Alzheimer’s disease via determination of the phospho-tau concentration in cerebrospinal fluid. 18th International Conference of Alzheimer’s Disease. Barcelona, Spain, October 23-26, 2002.

Additional useful information about Alzheimer’s disease can be found on the following websites:

The Alzheimer forum site:

http://www.alzforum.org/new/detail.asp?id=875

http://www.alzforum.org/new/detail.asp?id=804

http://www.alzforum.org/new/detail.asp?id=709
Documentation
Get access to this section and more

Create a free eServices account now and instantly access multiple digital resources:

Regulatory product documentation

Selected scientific posters

Product leaflets

How-to videos and more…

Register now or Sign in
Other documents

File

List_of_recommended_reading_publications_for_INNOTEST_Neuro.pdf (pdf, 154.35 kb)

File

INNOTEST Alzheimer panel brochure (pdf, 642.33 kb)

File

Whitepaper - Biomarkers for Alzheimers disease.pdf (pdf, 148.72 kb)

File

Practical guide for lumbar puncture.pdf (pdf, 263.94 kb)

File

NeuroSig v6-0 macro for use with INNOTEST Neuro assays (vnd.ms-excel.sheet.macroEnabled.12, 214.10 kb)

Extra information

This macro is used with all Neuro INNOTEST assays for calculating the concentrations based on the OD values obtained by a plate reader.
Get access to this section and more

Create a free eServices account now and instantly access multiple digital resources:

Regulatory product documentation

Selected scientific posters

Product leaflets

How-to videos and more…

Register now or Sign in
Insights

Alzheimer's disease

Use of the Aβ1-42/Aβ1-40 ratio to improve accuracy of AD diagnosis

It is widely agreed that, since cerebrospinal fluid (CSF) is in direct contact with the central nervous system (CNS), analytes measured in this body...

Nov 22, 2019

Read more

Alzheimer's disease

What is Alzheimer's disease?

Alzheimer’s disease, which is the most common form of dementia, is an incurable degenerative disease. Neurons in certain parts of the brain are...

Sep 30, 2019

Read more
Related products

INNOTEST® PHOSPHO-TAU (181P)

Product number 81581 -

Solid-phase enzyme immunoassay for the quantitative determination of phospho-tau(181P) in human cerebrospinal fluid (CSF).

For research use only

Detail

INNOTEST^® β-AMYLOID(1-42)

Product number 81576 -

Solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-42) in human cerebrospinal fluid (CSF).

CE marked

Detail

INNOTEST^® β-AMYLOID(1-42)

Product number 81583 -

Solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-42) in human cerebrospinal fluid (CSF).

For research use only

Detail

INNOTEST^® β-AMYLOID(1-40)

Product number 81585 -

Solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-40) in human cerebrospinal fluid (CSF).

For research use only

Detail

INNOTEST® β-AMYLOID(1-40)

Product number 80462 -

Solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-40) in human cerebrospinal fluid (CSF) in the clinical setting of dementia diagnosis.

CE marked

Detail

INNOTEST® hTAU Ag

Product number 81579 -

Solid-phase enzyme immunoassay for the quantitative determination of Tau protein in human cerebrospinal fluid (CSF).

For research use only

Detail

INNOTEST® hTAU Ag

Product number 81572 -

Solid-phase enzyme immunoassay for the quantitative determination of Tau protein in human cerebrospinal fluid (CSF).

CE marked

Detail

INNO-BIA™ plasma Aβ forms

Product number 81578 -

A well standardized multiparameter bead-based immunoassay for the simultaneous quantification of human β-amyloid (Aβ) forms Aβ1-42 and Aβ1-40 in plasma using xMAP® technology.

For research use only

Detail

Lumipulse^® G β-Amyloid 1-40

Product number 231524 -

Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of β-amyloid1-40 in human cerebrospinal fluid (CSF).

CE marked

Detail

Lumipulse^® G β-Amyloid 1-42

Product number 230336 -

Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of β-amyloid in human cerebrospinal fluid.

CE marked

Detail

Lumipulse^® G pTau 181

Product number 230350 -

Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of β-amyloid1-40 in human cerebrospinal fluid (CSF).

CE marked

Detail

Lumipulse^® G Total Tau

Product number 230312 -

Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of total Tau in human cerebrospinal fluid (CSF).

CE marked

Detail
Product inquiry

Salutation

First name

Last name

E-mail

Phone number

Organization / company

Company type

Function / job title

Message or question

Request support for

The provision of your data implies your consent to the processing of your data in our database and, depending on the option you choose, to receiving our monthly newsletter by e-mail.

For more information on how we process your personal data and regarding the rights you have in this respect, we refer to our privacy policy, which we hold at your disposal HERE.

If you no longer wish to receive our newsletter, you have the option to unsubscribe via the ‘unsubscribe’ tool at the bottom of the newsletter. If you want to have your data removed from our database, please contact us at: privacy@fujirebio.com.

Your local distributor(s) for this product

Fujirebio US, Inc.

205 Great Valley Parkway
Malvern PA, PA 19355
United States

001 877.861.7246
Toll-free: +1 877.861.7246. Hours of operation: Monday to Friday from 8:30am – 5:30pm EST.

Product support
001 877.861.7246

INNOTEST® PHOSPHO-TAU(181P)

Details

Features & Benefits

References

Documentation

Get access to this section and more

Other documents

Get access to this section and more

Insights

Related products

Product inquiry