Lumipulse® G PIVKA-II
Getting a better view on liver cancer
Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of protein induced vitamin K absence or antagonist-II (PIVKA-II) in serum.
The assay utilises proven CLEIA (ChemiLuminescent Enzyme Immunoassay) technology with results that are available in up to 35 minutes.
Product number 233184
Product number 233191
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- Allows stratification of patients on transplant waiting list.
- Predicts recurrence of HCC.
Complementary to AFP for improved detection of (early) HCC.
Only assay available on an automated platform (LUMIPULSE G1200)
Oncology menu available for routine, specialized and unique markers
Calibrators and controls available
Different clinical applications:
Monitoring: Correlation with microvascular invasion, recurrence and tumor size
Diagnosis: Complementary to AFP for the improved detection of HCC
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with a high rate of mortality and an increasing incidence.
The most common causes of HCC are either a viral hepatitis infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis).
The starting point in the diagnostic surveillance of at risk patients is ultrasound.
In a second stage this can be completed with the measurement of a tumor marker called α-fetoprotein (AFP).
Since ultrasound has a poor performance in cirrhotic patients and is also operator dependent, further characterization by CT or MRI is often required.
As it is important to detect HCC at an early stage when the disease is still curable, biomarkers can complete the diagnosis obtained with ultrasound before moving on to the more expensive MRI.
Biomarkers can also be used to better stratify patients on the liver transplant waiting list.
Additionally, the risk of recurrence of HCC after transplantation can be assessed by monitoring patients with biomarkers.
CLEIA - ChemiLuminescent Enzyme Immunoassay
See the LUMIPULSE G1200 working in this video:
Conditions of sale
To read the end user conditions of sale for this product please visit our Resource center.
PIKVA-II (Protein Induced Vitamin K Absence or Antagonist-II) is an immature form of prothrombin also known as DCP (Des-gamma-Carboxy Prothrombin)...
Sep 25, 2015
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Please see the following statement on the impact of coronavirus disease Covid-19 on the operations of Fujirebio Europe (updated January 19, 2021).
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Assayed control serum to monitor the precision of laboratory testing procedures for the analysis of PIVKA-II and KL-6 using LUMIPULSE Systems.CE marked
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Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the qualitative detection of antibody to hepatitis B e antigen (anti-HBe) in human serum or plasma. This product is indicated as an aid in the diagnosis and monitoring of hepatitis B viral infection and for professional use only.CE marked
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Immunoreaction cartridges set for in vitro diagnostics (IVD) use with the LUMIPULSE G System for the qualitative detection of hepatitis B e antigen (HBeAg) in human serum or plasma. This product is indicated as an aid in the diagnosis and monitoring of hepatitis B viral infection and for professional use only.CE marked
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Immunoreaction cartridges for in vitro diagnostics (IVD) use with the LUMIPULSE G System for the qualitative and quantitative detection of hepatitis B surface antigen (HBsAg) in human serum or plasma.CE marked
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