Epitope characterization has revealed five major antigenic domains of CEA, “Gold epitope 1-5”. High affinity IgG1 monoclonal antibodies (4x10-11 mol/L) against “Gold epitope 5” (12-140-1 MAb) and “Gold epitope 4” (12-140-10 MAb), are suitable for serological and immunohistochemical determination of CEA.
For the development of sensitive and specific assays for determination of CEA, the 12-140-10 MAb is recommended as catching antibody in combination with labeled 12-140-1-MAb as detecting antibody.
|12-140-1||IgG1||Purified||401-01R||Gold epitope group 5|
|12-140-10||IgG1||Purified||402-01R||Gold epitope group 4|