The MUC-1 breast cancer antigen is a mucin-type glycoprotein. It is secreted from tumor cells and can be used as a serological marker of breast cancer. The Ma552 and Ma695 antibodies to MUC-1 were characterized in the ISOBM TD4-workshop. The Ma552 monoclonal antibody epitope is located in the mucin polypeptide core and recognizes the hexapeptide [TRPAPG].
The Ma695 monoclonal antibody recognizes a sialylated carbohydrate epitope expressed on MUC-1 mucin.
|Ma552||IgG1||Purified||209-01R||Specific for the tandem repeat of the MUC-1 core protein (analogue to DF3). Epitope [TRPAPG].|
|Ma695||IgG1||Purified||204-01R||Carbohydrate on MUC-1 (analogue to 115D8).|