The MUC-1 breast cancer antigen is a mucin-type glycoprotein. It is secreted from tumor cells and can be used as a serological marker of breast cancer. The Ma552 and Ma695 antibodies to MUC-1 were characterized in the ISOBM TD4-workshop. The Ma552 monoclonal antibody epitope is located in the mucin polypeptide core and recognizes the hexapeptide [TRPAPG].
The Ma695 monoclonal antibody recognizes a sialylated carbohydrate epitope expressed on MUC-1 mucin.
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