On November 3, 1906, the German clinical psychiatrist and neuroanatomist Alois Alzheimer reported “A...
Scientific Poster - Clinical Validation of the Lumipulse® G β-Amyloid Ratio (1-42/1-40) in a Subset of ADNI CSF Samples
Oct 14, 2022
Background
The CSF Lumipulse G β-Amyloid Ratio (1-42/1-40)1 provides a potential
alternative to amyloid PET testing for patients with cognitive impairment to receive an
assessment of their brain amyloid status. Clinical validation of amyloid CSF biomarkers
for Alzheimer’s Disease (AD) is critical to ensure accurate assessment of patients. A
cutoff of 0.058 was previously established in the Amsterdam Dementia Cohort (ADC)2
consisting of 235 individuals with various cognitive impairments and complaints and
corresponding amyloid PET imaging results. Here we present validation of the cutoff in a
blinded clinical study of Alzheimer’s Disease Neuroimaging Initiative (ADNI)3 CSF
samples measured on the LUMIPULSE G1200.
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