Insights
Sep 9, 2022
The evolution of Alzheimer's disease diagnosis
By Rianne Esquivel, PhD and Francesca I. De Simone, PhD
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and is...
Jan 20, 2021
Comparison of Aβ1-42/Aβ1-40 ratio with other ratios
CSF Aβ1-42/Aβ1-40 is a tool thought to normalize atypical amyloid levels, whereas other ratios might be seen more as interpretation tools that allow...
Nov 16, 2020
The role of Aβ1- 40 in the Aβ1-42/Aβ1- 40 ratio
Aβ1-40 is the most abundant amyloid peptide in CSF, while Aβ1-42 accounts for only about 10% of the total Aβ peptide population.15 Total Aβ...
Oct 13, 2020
Aβ1-42/Aβ1-40 ratio to decrease preanalytical variability
- Aβ1-42 adsorption to plastic is a relevant preanalytical factor in laboratory practice.
- Adsorption to plastic seems to affect different Aβ isoforms...
Sep 9, 2020
Association between the CSF Aβ1- 42/Aβ1-40 ratio and amyloid PET
Most studies have found a strong association between CSF Aβ1-42 and amyloid PET measurements. However, in these studies, 10–20% of healthy individuals...
Jul 29, 2020
Understanding the Aβ1-42/Aβ1-40 ratio in relation to Alzheimer’s Disease
CSF Aβ1-42/Aβ1-40 ratio as a potential tool to detect amyloid deposition
