INNO-LIPA® CFTR Deletions+6
Reach the highest step in sensitivity
INNO-LiPA CFTR is a multiparameter line probe assay, based on the reverse hybridization principle, for the simultaneous detection and identification of 8 large rearrangements and 6 mutations and their wild-type sequences in human whole blood, dried blood spots, and buccal brush samples.
For the detection and identification of all ACMG mutations the INNO-LiPA CFTR 19 and INNO-LiPA CFTR 17+Tn Update kits are both required to be tested (testing for 35 mutations, one polymorphism and three Tn variants).
Well-defined study cohorts prove that large rearrangements in the CFTR gene account for 16-26% of unidentified CF alleles in various populations.
Large rearrangements, of which large deletions are the most common type, have a high clinical relevance as they will always lead to a severe form of the disease in presence of another CF causing mutation.
This strip contains mutations that have a significant frequency in Italy, Bulgaria, Turkey and Hispanic Countries.
Product number 81391